Cardiac Action Potential

Dr. Arslan Sarwar CardioVascular System January 19, 2019 | 0

The RMP (Resting membrane potential) is determined by the conductance to potassium ions. because

Basic Terminologies

Depolarization

It is caused by the movement of positive ions into the cardiac cell. Or inward current that brings positive charge/ions into the cell and causes depolarization of the cell membrane.

Repolarizatoin

It is caused by the movement of positive ions out of the cardiac cell. Or inward current that brings positive charge/ions out the cell and causes depolarization of the cell membrane.

Phases of Cardiac Action Potential

Phase 0

It is caused by a sudden increase in sodium inflow. this results in depolarization of the membrane. At the peak of action potential, the membrane potential approaches the sodium equilibrium potential.

Phase 1

Phase 1 begins with initial repolarization. It is caused by an increased outflow of potassium ions out of the cell and decreased inflow of the sodium ion.

Phase 2

It is the plateau of the action potential that is caused by a transient increase in calcium conductance inside the cell. During this phase, outward and inward currents are equal and thus maintains the plateau phase.

Phase 3

It is a phase of repolarization. calcium conductance is decreased in this phase and potassium conductance increases. Therefore the high potassium conductance results in large outflow of current which results in the hyperpolarization of the membrane. because

Phase 4

Phase 4 is the resting membrane potential.

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Cardiac Action Potential